Yes it is possible to do so. In fact, I have a '17 QX30 Premium with the Tech Pkg, and even though it came with the Bose speakers all around and a factory Bose Sub+Amp from I added a small 8" Phoenix Gold Subwoofer and amplifier. And, "Oh boy" does it sound amazing! I wasn't going for anything which would ultimately make my rear wipers rattle, but wanted to feel the bass when listening to music. The acoustics of the QX30 are excellent for smaller subwoofer enclosures. Trust me, you'll be blown away!